Month: November 2005

Abstract Nitric oxide (NO) regulates vascular tone and mitochondrial respiration. We investigated the hypothesis that there is reduced NO concentration in the renal cortex of diabetic rats that mediates reduced renal cortical blood perfusion and oxygen tension (Po2). Streptozotocin-induced diabetic and control rats were injected with l-arginine followed by Nω-nitro-l-arginine-metyl-ester (l-NAME). NO and Po2 were