Month: April 2015

April 27, 2015, by NCI Staff Staining slide showing range of PD-L1 expression in non-small cell lung carcinoma. Images courtesy of Dako North American, Inc. Findings from an early phase clinical trial may point to a biomarker that identifies patients with advanced non-small cell lung cancer most likely to respond to the immunotherapy drug pembrolizumab
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April 23, 2015, by NCI Staff A new NCI study forecasts important trends in breast cancer case types and molecular makeup.  Several studies have already forecasted that the incidence of U.S. breast cancer cases is expected to increase in the coming decades, largely the result of an aging population. Now, a new study presented by
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April 22, 2015, by NCI Staff Persistent infections with high-risk HPV types can cause cancer at several different anatomic sites. Persistent HPV infections, especially HPV-16, for example, are a key risk factor for oropharyngeal cancer, which involves the tonsils or the base of the tongue. Vaccination against high-risk types of human papillomavirus (HPV) protected young
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April 21, 2015, by Douglas Lowy, M.D. Douglas R. Lowy, M.D., during the Plenary Session: Precision Medicine Comes to Cancer Prevention and Screening at the American Association for Cancer Research Annual Meeting, April 20, 2015. © AACR/Phil McCarten 2015 Yesterday, at the annual meeting of the American Association for Cancer Research (AACR), I had my
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April 17, 2015, by NCI Staff Cancer surveillance science involves understanding and reporting the most relevant and available patient information to provide a complete picture of a patient’s cancer. On April 15, NCI’s Surveillance, Epidemiology, and End Results (SEER) Program published the latest data on U.S. cancer incidence. Since the early 1970s, SEER has been
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April 15, 2015, by NCI Staff Imaged using a technique known as spectral karyotyping, these chromosomes, prepared from a glioblastoma sample, reveal an enormous degree of chromosomal instability—a hallmark of cancer. Microscopes have come a long way since 17th-century English scientist Robert Hooke peered through his leather- and gold-tooled instrument and discovered the cell.  Today’s
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April 14, 2015, by Robert Croyle, Ph.D. Robert Croyle, Ph.D., Director, Division of Cancer Control and Population Sciences Ongoing concerns regarding the cost and quality of cancer care have led many organizations to focus greater attention on the non-biological factors that contribute to variation in outcomes. Health care delivery systems are struggling to understand how best
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April 9, 2015, by NCI Staff Often described as heart-shaped, the RAS protein plays an important role in cell division and growth. Every year, more than one million people worldwide die from cancers driven by mutations in a gene called RAS. Despite the success in developing cancer therapies that target many genetic abnormalities that drive
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April 9, 2015, by NCI Staff Frank McCormick, Ph.D.RAS National Program AdvisorProfessor Emeritus, UCSF Helen Diller Family Comprehensive Cancer Center Frank McCormick, Ph.D., leads the NCI-sponsored RAS Initiative at the Frederick National Laboratories for Cancer Research (FNLCR). In this interview, Dr. McCormick talks about the history, the challenges, and the future of RAS research. What
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April 1, 2015, by Douglas Lowy, M.D. Douglas R. Lowy, M.D.Deputy Director, National Cancer Institute As many of you are aware, I have become Acting Director of the National Cancer Institute (NCI). I have known many of you for years, and look forward to working together in my new role at the Institute. I would
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