Month: September 2016

September 30, 2016, by NCI Staff Research from an NCI-funded program studying a group of rare and hard-to-treat childhood cancers has set the stage for two Children’s Oncology Group-led clinical trials that are evaluating new treatment options for children with acute lymphoblastic leukemia (ALL). The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative is
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Truth: Your body and symptoms should guide you. There are two groups of people who absolutely must cut gluten. People who have the autoimmune disorder celiac disease need to strictly avoid it, because even small amounts cause their immune system to damage or destroy villi, the tiny, fingerlike outgrowths that line the small intestine. When
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September 29, 2016, by NCI Staff As oxygen levels around cells drop, HIF-2α accumulates in the cell nucleus and binds to the protein ARNT to form the HIF-2 transcription factor. HIF-2 controls the transcription of genes that can promote tumor development. Credit: Richard Bruick, Kevin Gardner, UT Southwestern Cancer Center Two new studies show that a
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September 27, 2016, by NCI Staff Many family members who care for loved ones with cancer do not feel adequately prepared for the caregiving tasks they assume and need help to make informed decisions about end-of-life care, according to a new study. “Our study found that many cancer caregivers experience high levels of emotional stress,”
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September 23, 2016, by NCI Staff Chromosomes (purple) being pulled apart during cell division. If this process goes awry, a cell can be left with the wrong number of chromosomes or damaged chromosomes, which can drive cancer development. Credit: Nasser Rusan, National Heart, Lung, and Blood Institute A team led by researchers from the Lawrence
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September 22, 2016, by Douglas R. Lowy, M.D. NCI Acting Director Doug Lowy, Director of the White House Office of Science and Technology Policy John P. Holdren, Vice President Joe Biden, HHS Secretary Sylvia Burwell, and NIH Director Francis Collins (left to right) meeting with health leaders from Japan and Korea in New York City
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September 16, 2016, by Sheila Prindiville, M.D., M.P.H and Michael Balint Cancer clinical trials are a critically important step on the pathway for new or improved treatments to make their way to patients in clinics and hospitals in towns and cities across the country. Patients and their loved ones are relying on these rigorous studies
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September 14, 2016, by NCI Staff Dr. Greg Armstrong, principal investigator of the Childhood Cancer Survivor Study, with a study participant. Credit: St. Jude Children’s Research Hospital September is Childhood Cancer Awareness month, an opportunity to learn more about pediatric cancer. Thanks to treatment advances, 83% of children diagnosed with cancer will survive at least 5
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September 12, 2016, by NCI Staff A new study has shown that nutrients provided by neighboring cells drive metabolism in the mitochondria (red) of pancreatic ductal adenocarcinoma cells. Credit: National Cancer Institute Pancreatic cancer cells grow by instructing neighboring cells to provide them with nutrients, a new study published online August 10 in Nature has
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September 9, 2016, by Douglas R. Lowy, M.D. On September 7, Blue Ribbon Panel co-chairs Elizabeth Jaffee, Ph.D. (left), Tyler Jacks, Ph.D., and Dinah Singer, Ph.D., presented the panel’s report to the National Cancer Advisory Board. Credit: National Cancer Institute Listening to the presentation of the Cancer Moonshot Blue Ribbon Panel report at the National
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September 7, 2016, by NCI Staff Currently, patients who need a stem cell transplant first receive high-dose chemotherapy and radiation to destroy blood-forming cells. Researchers tested a new method of transplant in mice that does not require this preparative therapy. Credit: Terese Winslow In a proof-of-concept study in mice, researchers from the Stanford University School
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80% of patients who believed that they were allergic to penicillin received more effective therapy after penicillin skin allergy testing. Penicillin is a common antibiotic that is used to treat infections caused by bacteria. Up to 15% of patients admitted to hospitals report that they have an alleged allergy to penicillin. While penicillin allergies can
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Abstract Glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway, plays important roles in redox regulation and de novo lipogenesis. It was recently demonstrated that aberrant upregulation of G6PD in obese adipose tissue mediates insulin resistance as a result of imbalanced energy metabolism and oxidative stress. It remains elusive, however, whether inhibition of
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September 1, 2016, by NCI Staff Neural stem cells transformed with cancer-causing genes found in high-risk medulloblastoma grow as translucent spheres in cell culture (left panel). Transformed neural stem cells (blue) invading and destroying normal brain tissue (pink) in mice (right panel). Credit: Allison Hanaford and Eric Raabe, Johns Hopkins Kimmel Cancer Center In search
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