Month: January 2017

Chemicals and reagents For this study, roxatidine (≥98% purity, Fig. 1A), primary antibodies for p65, p–IκBα, IκBα, p-ERK, p-p38, p-JNK, ERK, p38, JNK, PARP, α-tubulin, caspase-1, MKK3/6, MAPK-activated protein kinase 2 (MK2), and β-actin and peroxidase-conjugated secondary antibodies were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA, USA). p-IKK, IKK, p-Akt, Akt, p-MKK3/6, and
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January 30, 2017, by NCI Staff When tumors metastasize to the bone (orange), osteoclasts (red) promote the breakdown of bone and promote the growth of cancer cells (purple). Credit: National Cancer Institute Patients with cancer that has spread to their bones can receive less-frequent treatments to prevent fractures and other bone-related complications without sacrificing efficacy
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January 25, 2017, by NCI Staff Key features of gastroesophageal carcinoma subtypes. The colored bands represent the proportion of the subtypes present within each anatomic region. Credit: TCGA Research Network In a large-scale genomic study, researchers have characterized the genetic alterations in more than 160 cancers of the esophagus, the tube that connects the mouth
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Burn fat and build muscle with these exercises from celebrity trainer Jason Walsh.  In La La Land, Emma Stone goes on a sing-and-dance journey through Los Angeles—and boy does all that tap dancing look tiring. We wondered what Stone did to build the strength and stamina needed for long days of dancing and singing on set, so
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A consultation paper proposing a risk-based approach to regulation of “self-care” products represents significant change in how cosmetics, natural health products and non-prescription drugs are regulated in Canada. Health Canada is responsible for regulation of both prescription and non-prescription (or “self-care”) products sold in Canada. Self-care products cover three categories of goods: Cosmetics, which includes
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January 18, 2017, by NCI Staff NCI recently released The Economics of Tobacco and Tobacco Control, the latest in a series of monographs on tobacco use and tobacco control. Produced in collaboration with the World Health Organization, the new report examines the current research surrounding the economics of tobacco control in many countries around the
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January 11, 2017, by NCI Staff Widespread skin rashes are among the common symptoms of chronic graft-versus-host disease. Credit: S.R. Riddell, F.R. Applebaum PLOS Med 2007; DOI: 10.1371/journal.pmed.0040198 (CC BY 1.0) The targeted cancer therapy ibrutinib (Imbruvica®) can effectively treat a common and serious complication of a type of stem cell transplant, findings from a small
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Isolation and preparation of Weissella cibaria WIKIM28 Weissella cibaria WIKIM28 was isolated from gatkimchi manufactured in the province of Jeollanam-do, Republic of Korea. First, the gatkimchi was homogenized in stomacher, and the homogenate was filtered through stomacher filter bag. This filtered homogenate was diluted by dilution and spread onto de Man, Rogosa, and Sharpe (MRS;
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January 4, 2017, by NCI Staff A drug most commonly used to treat depression may also reduce joint pain in some women being treated for early-stage breast cancer, according to the results of a randomized clinical trial. After undergoing treatment for early-stage breast cancer, many postmenopausal women take drugs known as aromatase inhibitors to reduce
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