Month: August 2017

Researchers find that proactively removing more than 24 lymph nodes can help the long term outcome of patients with Oral Cavity Squamous Cell Carcinoma. Surgical nodal dissection or excision involves removing lymph nodes affected by cancer and simultaneously determining the stage of cancer.Benefits of such measures include staging cancer and limiting the spread of cancer
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Scientists compared three anti-epileptic drugs including one branded Lamotrigine and two lamotrigine-generic drugs and found them to be bioequivalent. Now we know: branded and generic drugs can be substituted with confidence. It is estimated that nearly 80% prescriptions filled in the US are for generic drugs. The US Food and Drug Administration (FDA) requires that
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Scientists at the Center for Injury Research and Prevention at the Children’s Hospital of Philadelphia asked the question; “what is the association between attention-deficit/ hyperactivity disorder (ADHD) and car crashes involving young adult drivers, and does this vary by sex, licensing age, and/or being prescribed ADHD medication?” Car crashes are the leading cause of death
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August 31, 2017, by Matthew Goetz, M.D. Many stories of successful cancer research follow a familiar arc: one of curiosity, iteration, collaboration, and persistence. The development of endoxifen, an investigational drug for breast cancer, is no different. Like many research advances, the endoxifen story started with intriguing basic research findings that the research community continuously
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In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms. Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound effects on
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August 30, 2017, by NCI Staff Researchers have developed a treatment that targets stiff components of the extracellular matrix (blue) surrounding metastatic cancer cells (red) as a potential therapy for metastatic cancer. Credit: Jenu Chacko, Ph.D. and Linan Liu, Ph..D., University of California, Irvine Researchers have used modified stem cells to deliver a cancer drug
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Brain gene expression associated with depression differed markedly between men and women in a study by NIMH-funded researchers.  Such divergent “transcriptional signatures” may signal divergent underlying illness processes that may require sex-specific treatments, they suggest. Experiments in chronically-stressed male and female mice that developed depression-like behaviors largely confirmed the human findings. NIMH grantee Eric Nestler,
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August 28, 2017, by NCI Staff Human cells surrounded by acute myelocytic leukemia cells (purple).  Credit: National Cancer Institute The Food and Drug Administration (FDA) recently approved two new treatments for some adult patients with acute myeloid leukemia (AML): enasidenib (Idhifa®), a drug that targets aberrant forms of the IDH2 protein; and liposomal cytarabine-daunorubicin CPX-351 (Vyxeos™),
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A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer. Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with locally
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A meta-analysis combining results across studies assessed outcomes of tight versus standard glucose management on the prevention of onset and progression of end-stage kidney disease (ESKD) in diabetic patients. Study results suggest that diabetic patients who were under stringent glucose control have a comparable risk of kidney failure to those under standard glucose management. Diabetes
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This article originally appeared on Life by Daily Burn.  You know that a heart-pumping workout is good for your body and mind. But if your sweat sesh leaves you with an upset stomach or running from the streets to the bathroom, it might not be so coincidental. According to new research published in Alimentary Pharmacology & Therapeutics, intense exercise may
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Chronic kidney disease is both a cause and consequence of hypertension. In patients with both conditions, accurate evaluation and a tailored treatment program are essential for successful hypertension management. Blood circulates through the body at a certain pressure within the arteries. This pressure changes depending on activity levels– elevating during exercise, to increase the blood
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WASHINGTON – Doctors from the Sheik Zayed Institute for Pediatric Surgical Innovation at Children’s National Health System have completed a clinical trial that demonstrates how osteoid osteoma, a benign but painful bone tumor that commonly occurs in children and young adults, can be safely and successfully treated using an incisionless surgery method called magnetic resonance-guided high-intensity
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence. Stress urinary incontinence, or
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The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS). The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence by
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August 23, 2017, by NCI Staff FDA has approved neratinib as additional adjuvant therapy in women with early-stage (stage I to III) HER2-positive breast cancer. Credit: National Cancer Institute On July 17, the Food and Drug Administration (FDA) approved neratinib (Nerlynx™) to prevent recurrence in patients with early-stage HER2-positive breast cancer who have finished at
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Cardiovascular diseases are currently the leading cause of mortality worldwide. A group of researchers led by Jeffrey Cohen introduced a new method of preventing heart attacks using photosynthetic bacteria. According to the World Health Organization, cardiovascular diseases are the leading cause of mortality worldwide. Different strategies are being studied to improve
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A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence. Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
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WASHINGTON – Those parents you overhear transforming trips to the grocery store into sensory adventures—telling babies too young to babble that broccoli is GREEN, radishes are RED and tangerines are ORANGE—are onto something. Being exposed to a complex and stimulating environment rich with new sights, sounds and a full vocabulary can play a powerful role
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Diabetic foot ulcers are one of the most common complications affecting diabetic patients. A recent review article outlines preventative measures that can decrease the odds of developing foot ulcers. Diabetic foot ulcers, especially on the bottom of the foot, are a common problem in diabetics. Up to 26.1 million diabetic patients worldwide are estimated to
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PET scanning revealed elevated translocator protein in several regions comprising the neurocircuitry of Obsessive Compulsive Disorder (OCD), indicating a pathogenic role for microglia in the neuropathogenesis of OCD. Though several Hollywood stars have been diagnosed with OCD, no one is better remembered for suffering from this debilitating condition than Howard Hughes of ‘The Aviator’. Characterized
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