Month: September 2017

Olaparib (Lynparza) is a treatment for advanced ovarian cancer in patients carrying inherited mutations in the BRCA gene. A study compares olaparib with standard drugs for the treatment of metastatic breast cancer in patients with inherited BRCA mutation. Mutations in BRCA1 and BRCA2, the tumor suppressor genes that code for proteins involved in DNA repair,
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Comparing the effectiveness of an immunotherapy inhibitor, nivolumab, with platinum-based chemotherapy may help oncologists determine which drug is most beneficial as a first line treatment for patients with advanced or recurrent non-small-cell lung cancer. As its name suggests, platinum-based chemotherapy contains complexes of the metal platinum, which can bring along an entourage of symptoms. Though
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Is it true that smoking causes wrinkles? Answers from J. Taylor Hays, M.D. Yes. So if you need another reason to motivate you to quit smoking, add premature wrinkles to the list. Smoking can speed up the normal aging process of your skin, contributing to wrinkles. These skin changes may occur after only 10 years
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The essential oils found in Curcuma herbs have many uses. Researchers in China determine the composition and therapeutic activity of Curcuma herb essential oils extracted from four Curcuma herb species. Curcuma herbs have been used in Southeast Asia for thousands of years for their claimed antioxidative, antimicrobial, anti-inflammatory, and cytotoxic effects. the chemical composition of
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Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
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A recent analysis of geriatric patients hospitalized through emergency departments shows that proper geriatric assessments of older patients may reduce admission rates. A recent article published in Age and Ageing by the Oxford University Press reviewed the evidence behind performing comprehensive geriatric assessments (CGA) for more elderly patients that present at the emergency department. The
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Statistics show that in 2015, the number of practicing doctors above the age of 65 was 23% of all health professionals. This percentage has increased by more than 374% since the year 1975. More than ever, we are left to wonder: what is the appropriate physician retirement age? There is concern regarding the ability of
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September 29, 2017, by J. Guidry Auvil, Ph.D., and M. Smith, M.D., Ph.D. Earlier this month, researchers gathered in Rockville, MD, for the first annual meeting of an important NIH-sponsored initiative that will expand research on childhood cancers and certain types of birth defects. The initiative, the NIH Common Fund’s Gabriella Miller Kids First Pediatric
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Researchers speculate that new changes in government could potentially take away the benefits from a program introduced in 1997 to reduce health disparities in the United Kingdom between different geographical locations. Unemployment in the United Kingdom (UK) was on the rise in the 1980s and 1990s. The unemployment fuelled the income inequality within the country.
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In a recent study, researchers sought to identify proteins important for the anti-neural plasticity effects of histone deacetylase 2 (Hdac2) in Alzheimer’s disease. How Cells Control Gene Activity Acetylation is one method by which cells control gene activity by the addition or removal of acetyl groups. Acetylation is performed by enzymes called acetyltransferases on histone
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Vasodilatory shock resistant to traditional treatment with vasopressors is associated with a high mortality rate A recent study published in The New England Journal of Medicine sets out to investigate the effects of angiotensin II as a treatment. Shock can be a fatal syndrome as a result of decreased perfusion of vital organs which leads
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Doug Mackenzie is a professional photographer based in Bainbridge Island, Washington. He has been a squamous cell carcinoma survivor for 6 months. My story is from the perspective of a person who had, for the most part, been a very healthy man for 63 years of his life. No major health issues beyond some high
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September 28, 2017, by NCI Staff A bone marrow smear from a patient with acute myeloid leukemia. Credit: Armed Forces Institute of Pathology On September 1, the Food and Drug Administration (FDA) approved gemtuzumab ozogamicin (Mylotarg™) for some patients with acute myeloid leukemia (AML). The approval covers the use of gemtuzumab in adults with newly
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Attitudes toward breastfeeding have a chequered past despite the many positive health benefits it provides and its association with children’s cognitive development. Currently, the UK has one of the lowest rates of breastfeeding in the world, mainly due to social attitudes. Although policies promoting breastfeeding have been introduced in the UK, it appears that greater
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According to recent studies, ductal carcinoma in situ, a non-invasive benign tumour of the breast, is over-diagnosed and therefore overtreated. An unfortunate reaction to overtreatment of benign breast tumours might be a decrease of the active surveillance of the breast tissue which causes patients to be underdiagnosed for invasive ductal carcinoma. Tumours can either be
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The CRISPR-Cas9 screening method has identified the genes that play a role in the body’s immune response to tumors. This important discovery will help to improve the results of cancer immunotherapy. Cancer cells are known to often contain genetic mutations. However, other non-cancerous cells within the body may also contain mutations which can either hinder
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Genome-wide association studies for many neurological disorders have limiting factors that cause the inability to draw significant clinical outcomes. Recently, studies have overcome these limitations for three neurological disorders, including multiple sclerosis, Alzheimer’s, and Huntington’s disease. A number of genome-wide association studies have provided important information on neurological disorders such as multiple sclerosis, with over
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Hydration health issues in the elderly have significant economic effects and while most elderly people recognize the importance of proper hydration, there may be limited health literacy including knowledge of signs and symptoms and health consequences of improper hydration. Dehydration is caused by excess fluid loss from the body and can lead to serious health
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Medication administration and management is a real problem in patients suffering from medical conditions associated with cognitive deficits. A recent study examined the experience of family members as they help take care of elder family members with Alzheimer’s disease. Compliance is an ongoing issue in medicine, particularly for elderly patients with medical conditions that cause
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In a 2017 study, researchers explored the association between single nucleotide polymorphisms of the C-reactive protein gene and age-related macular degeneration. The findings suggest that C-reactive protein does not cause macular degeneration. Associations have been drawn between high levels of the inflammatory biomarker C-reactive protein (CRP) and age-related macular degeneration (AMD) – deterioration of the
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If you’ve heard of the ketogenic diet, you’re probably aware that there’s no limit to the information you can find on it online. However, finding solid, research-supported information about this strict eating plan is more difficult. In this podcast, dietitian Annette Goldberg and neuro-oncologist Dr. Roy Strowd examine the science around the ketogenic diet and
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