Aging

Potentially inappropriate medications (PIMs) usage is associated with adverse complications in the older adult population. In a recent study, researchers determine the costs associated with PIMs and the difference between cases in residential care and traditional aged facilities.   Polypharmacy is the concurrent use of numerous drugs to treat a single condition. Individuals prescribed more
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Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study, published in The Lancet Public Health journal, of over one million adults diagnosed with dementia in France. This study looked specifically at the effect of alcohol use
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Physicists have devised a new method of investigating brain function, opening a new frontier in the diagnoses of neurodegenerative and aging related diseases. This new non-invasive technique could potentially be used for any diagnosis based on cardiovascular and metabolic-related diseases of the brain. The researchers at Lancaster University (UK) and Medical University of Gdansk (Poland)
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Scientists have more evidence that exercise improves brain health and could be a lifesaving ingredient that prevents Alzheimer’s disease. In particular, a new study from UT Southwestern’s O’Donnell Brain Institute suggests that the lower the fitness level, the faster the deterioration of vital nerve fibers in the brain. This deterioration results in cognitive decline, including
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A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine,
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Little hints of immortality are lurking in fruit flies’ stem cells. Stem cells that produce sperm use a genetic trick to stay perpetually young across generations, Howard Hughes Medical Institute (HHMI) Investigator Yukiko Yamashita and colleagues have discovered. Certain sections of the fruit fly genome get shorter with age. But remarkably, some reproductive cells can
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Researchers from East Carolina University performed a study using mice to look at the effects of exercise in reversing metabolic dysfunction in Alzheimer’s disease. Alzheimer’s disease (AD) is a neurological degenerative condition that leads to cognitive decline and memory loss. Alzheimer’s disease is strongly associated with aging and it is believed that over time, specific
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USC research sheds new light on how a breakdown in the brain’s vascular system predates the accumulation of toxic plaques and tangles in the brain that bring about Alzheimer’s disease. The research suggests an earlier target for preventing dementia and Alzheimer’s. Nearly 50 percent of all dementias, including Alzheimer’s, begins with the breakdown of the
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While most treatments for Alzheimer’s disease focus on improving memory, researchers at The Ohio State University Wexner Medical Center conducted a study aimed at slowing the decline of problem-solving and decision-making skills in these patients. For the first time ever, thin electrical wires were surgically implanted into the frontal lobes of the brains of patients
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Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) has succeeded in curing this disease in mice using a gene therapy that lengthens the telomeres. This work constitutes a “proof of
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Researchers examined the relationship between gait stability and physical activity in older adults performing treadmill exercises. Walking is a good physical activity, and previous studies have found that it provides improved gait stability in the elderly. As published in the European Review of Aging and Physical Activity, researchers recently used treadmill exercises to evaluate the
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According to a study by scientists of the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn now published in the journal Nature, inflammatory mechanisms caused by the brain’s immune system drive the progression of Alzheimer’s disease. These findings, which rely on a series of laboratory experiments, provide new insights into pathogenetic mechanisms
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Researchers from Toronto reveal an innovative approach to study brain changes linked to working memory loss in people with Alzheimer’s disease. Alzheimer’s Disease and Dementia Dementia is a general term for the loss of memory and other cognitive skills. Unlike cognitive impairment associated with normal aging, the cognitive decline associated with dementia is serious enough
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A recent study investigated whether there is a link between consuming high glycemic foods and the accumulation of amyloid-β plaques in older adults. More than one in eight Americans aged over 65 years is affected by Alzheimer’s disease, the most common form of dementia. The hallmark characteristic of Alzheimer’s disease is the formation and accumulation
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A new large-scale international study expands the number of genetic markers now known to be associated with exceptional longevity. Researchers at the University of Connecticut, University of Exeter, University of Wisconsin and University of Iowa undertook a genome-wide search for variants influencing how long participants’ parents lived. Their findings indicated genes that could one day
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About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year, according to a new study by researchers at the UCLA Fielding School of Public Health. The findings highlight the need to develop measures that could slow the progression of the disease in people
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In the December featured basic science article in The Journal of Nuclear Medicine, Belgian researchers report on the first large-scale longitudinal imaging study to evaluate BACE1 inhibition with micro-PET in mouse models of Alzheimer’s disease. PET imaging has been established as an excellent identifier of the amyloid plaque and tau tangles that characterize Alzheimer’s disease.
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DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific
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Using ‘Raman’ optical technology, scientists of the University of Twente in The Netherlands, can now produce images of brain tissue that is affected by Alzheimer’s disease. The images include the surrounding areas, already showing changes. Alzheimer’s disease is associated with areas of high protein concentration in brain tissue: plaques and tangles. Raman imaging is now
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In a comprehensive analysis of samples from 107 aged human brains, researchers at the Allen Institute for Brain Science, UW Medicine and Kaiser Permanente Washington Health Research Institute have discovered details that will help researchers better understand the biological bases for Alzheimer’s disease and dementia in older populations. The analysis also highlights surprising variability in
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Heavy drinking and smoking are linked to visible signs of physical aging, and looking older than one’s years, suggests research published online in the Journal of Epidemiology & Community Health. Light to moderate drinking was not associated with biological aging, the findings showed. But nor was it linked to the slowing of the visible aging
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Population-based data on human biological growth and development processes are fundamental for assessing the health status of a community. For many populations in rural Africa, birth registry and eliciting date of birth are still challenges. Data on uncompromised development and growth variation in most developing populations are surprisingly lacking, and researchers typically compare growth in
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