Aging

A recent study investigated whether there is a link between consuming high glycemic foods and the accumulation of amyloid-β plaques in older adults. More than one in eight Americans aged over 65 years is affected by Alzheimer’s disease, the most common form of dementia. The hallmark characteristic of Alzheimer’s disease is the formation and accumulation
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A new large-scale international study expands the number of genetic markers now known to be associated with exceptional longevity. Researchers at the University of Connecticut, University of Exeter, University of Wisconsin and University of Iowa undertook a genome-wide search for variants influencing how long participants’ parents lived. Their findings indicated genes that could one day
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About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year, according to a new study by researchers at the UCLA Fielding School of Public Health. The findings highlight the need to develop measures that could slow the progression of the disease in people
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In the December featured basic science article in The Journal of Nuclear Medicine, Belgian researchers report on the first large-scale longitudinal imaging study to evaluate BACE1 inhibition with micro-PET in mouse models of Alzheimer’s disease. PET imaging has been established as an excellent identifier of the amyloid plaque and tau tangles that characterize Alzheimer’s disease.
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DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific
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Using ‘Raman’ optical technology, scientists of the University of Twente in The Netherlands, can now produce images of brain tissue that is affected by Alzheimer’s disease. The images include the surrounding areas, already showing changes. Alzheimer’s disease is associated with areas of high protein concentration in brain tissue: plaques and tangles. Raman imaging is now
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In a comprehensive analysis of samples from 107 aged human brains, researchers at the Allen Institute for Brain Science, UW Medicine and Kaiser Permanente Washington Health Research Institute have discovered details that will help researchers better understand the biological bases for Alzheimer’s disease and dementia in older populations. The analysis also highlights surprising variability in
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Heavy drinking and smoking are linked to visible signs of physical aging, and looking older than one’s years, suggests research published online in the Journal of Epidemiology & Community Health. Light to moderate drinking was not associated with biological aging, the findings showed. But nor was it linked to the slowing of the visible aging
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Population-based data on human biological growth and development processes are fundamental for assessing the health status of a community. For many populations in rural Africa, birth registry and eliciting date of birth are still challenges. Data on uncompromised development and growth variation in most developing populations are surprisingly lacking, and researchers typically compare growth in
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Mushrooms may contain unusually high amounts of two antioxidants that some scientists suggest could help fight aging and bolster health, according to a team of Penn State researchers. In a study, researchers found that mushrooms have high amounts of the ergothioneine and glutathione, both important antioxidants, said Robert Beelman, professor emeritus of food science and
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Treatment with a neuroprotective compound that saves brain cells from dying also prevents the development of depression-like behavior and the later onset of memory and learning problems in a rat model of Alzheimer’s disease. Although the treatment protects the animals from Alzheimer’s-type symptoms, it does not alter the buildup of amyloid plaques and neurofibrillary tangles
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Understanding the factors that control aging has been one of humanity’s endless pursuits, from the mystical fountain of youth to practical healthful regimens to prolong life expectancy. A team of scientists at the University of California San Diego has helped decipher the dynamics that control how our cells age, and with it implications for extending
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Researchers determine whether there is an association between aggressive treatment of hypertension and cognition function. Despite the relationship between hypertension and cognition being well established, recent concerns have arisen surrounding the treatment of hypertension. This concern is due to suspicions that more aggressive hypertension treatment, particularly in the elderly, may actually be linked to adverse
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Researchers at Lund University in Sweden have for the first time convincingly shown where in the brain the earliest signs of Alzheimer’s occur. The discovery could potentially become significant to future Alzheimer’s research while contributing to improved diagnostics. In Alzheimer’s, the initial changes in the brain occur through retention of the protein, ?-amyloid (beta-amyloid). The
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In hopes to find a new treatment for Alzheimer’s, researchers determine if toxic tau tangles are the primary drivers responsible for the disease. The two pathological hallmarks of the devastating neurodegenerative disorder, Alzheimer’s disease, are amyloid plaques and tau protein tangles. Amyloid plaques and tau protein tangles are two brain abnormalities of Alzheimer’s disease. Amyloid
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Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body. The findings, published today in Molecular Psychiatry, offer hope that future drug therapies might be able
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A major study by researchers at William & Mary’s Virginia Institute of Marine Science shows that many diverse species of Chesapeake Bay fishes — whether they eat zooplankton, other fishes, or bottom-dwelling invertebrates — exhibit similar year-to-year trends in a common measure of their overall health. VIMS Professor Rob Latour says the study provides “useful
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A recent meta-analysis investigates whether sex, age, and a particular genotype are associated with a greater risk of developing Alzheimer’s disease. Alzheimer’s Disease (AD) is a chronic neurodegenerative condition, characterized by cognitive deficits in memory, thinking, and behaviour. Research has shown that different environmental, genetic, and socioeconomic cues can increase the risk of developing Alzheimer’s
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The relationship between memory and time has been studied extensively but is still poorly understood. A new study assessed memory and time deficits in Alzheimer’s disease (AD) patients in their home environments. It is widely accepted that as time passes, the ability to recall events and specific information declines. Episodic memory is the type of
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A recent analysis of geriatric patients hospitalized through emergency departments shows that proper geriatric assessments of older patients may reduce admission rates. A recent article published in Age and Ageing by the Oxford University Press reviewed the evidence behind performing comprehensive geriatric assessments (CGA) for more elderly patients that present at the emergency department. The
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In a recent study, researchers sought to identify proteins important for the anti-neural plasticity effects of histone deacetylase 2 (Hdac2) in Alzheimer’s disease. How Cells Control Gene Activity Acetylation is one method by which cells control gene activity by the addition or removal of acetyl groups. Acetylation is performed by enzymes called acetyltransferases on histone
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Medication administration and management is a real problem in patients suffering from medical conditions associated with cognitive deficits. A recent study examined the experience of family members as they help take care of elder family members with Alzheimer’s disease. Compliance is an ongoing issue in medicine, particularly for elderly patients with medical conditions that cause
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