Cancer

The study of how the immune system recognizes friend and foe, or as the immunologist Sir Macfarlane Burnet phrased it, “distinguishes between self and non-self,” has driven important discoveries that are transforming our ability to treat cancer. Over the last century, scientists and clinicians have unraveled the complex interactions (both in innate and adaptive immunity)
0 Comments
February 02, 2018 Pomalidomide, an immunomodulatory agent with anti-myeloma activity, is metabolized primarily by the liver, suggesting that patients with renal impairment can safely receive the drug. Pomalidomide plus low-dose dexamethasone may be effective, though highly toxic, among patients with relapsed/refractory multiple myeloma and renal impairment,
0 Comments
For a tumour to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumour vascularization is therefore an interesting anti-tumour therapy that has been explored over the last ten years. But how to be truly effective? By identifying two cytokines, key factors in the recruitment of blood cells essential to the formation
0 Comments
February 01, 2018 Previous studies demonstrated that patients with metastatic hormone-sensitive prostate cancer treated with docetaxel have prolonged overall survival. Chemohormonal therapy prolongs overall survival among patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC), according to a study published in the Journal of Clinical Oncology.1 Interim
0 Comments
What happens when the most common and least threatening type of cancer gets complicated? A new study pinpoints a mechanism that controls how basal cell cancers respond to treatment and offers new ideas for controlling this disease when it gets tricky. Basal cell carcinomas are incredibly common — somewhere between 1 million to 3 million
0 Comments
“Hairy” nanoparticles made with light-sensitive materials that assemble themselves could one day become “nano-carriers” providing doctors a new way to simultaneously introduce both therapeutic drugs and cancer-fighting heat into tumors. That’s one potential application for a new technology that combines water-repelling yet light-sensitive and water-absorbing materials into polymeric nano-reactors for creating photo-responsive gold nanoparticles. Light
0 Comments
February 01, 2018 This article originally appeared on Psychiatry Advisor. Previous epidemiological studies have indicated inconsistent results regarding the correlation between antidepressant use and ovarian cancer risk. Duration and intensity of antidepressant treatment does not have an impact on epithelial ovarian cancer risk, according to
0 Comments
Meredith Carothers is a Food Safety Education Intern at the Food Safety and Inspection Service of the United States Department of Agriculture (USDA). It’s time for the Super Bowl, so you may be hosting a big party or going to one. And where there’s a Super Bowl viewing party, there’s also plenty of food. No
0 Comments
The BCR-ABL tyrosine kinase inhibitors (TKIs) were an early example of a successful targeted cancer treatment and have dramatically improved outcomes for patients diagnosed with chronic myeloid leukemia (CML) — and advances in TKI treatment continue to accumulate.1-4 Imatinib, dasatinib, and nilotinib are now US Food and Drug Administration (FDA)-approved for the first-line treatment of
0 Comments
Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. The approach works for many different types of cancers, including those that arise spontaneously, the study
0 Comments
Scientists have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. Viruses have their own genetic material and can infect human
0 Comments
Hypofractionated external beam radiotherapy (EBRT) delivers the total prescribed therapeutic radiation dose in fewer, larger-dose fractions than standard radiotherapy dose schedules, accelerating treatment time. “The key advantages of moderate hypofractionation, owing to its shorter treatment courses, are lower cost and greater convenience for patients,” said Scott Morgan, MD, assistant professor of radiation oncology at the University
0 Comments
At the start of every year, the American Society of Clinical Oncology (ASCO) releases its Clinical Cancer Advances report. This in-depth report is published in ASCO’s Journal of Clinical Oncology and covers the major advances made in cancer care over the past year, including prevention, treatment, patient care, and a look toward the future. Each
0 Comments
January 30, 2018, by NCI Staff Credit: National Cancer Institute An NCI-funded study has found that, at the genetic level, acute myeloid leukemia (AML) differs greatly between younger and older patients. “AML in younger patients and AML in older patients are entirely distinct diseases,” said the study’s senior investigator, Soheil Meshinchi, M.D., Ph.D., of Fred
0 Comments
Injecting breast cancer with oxygen-filled microbubbles makes tumors three-times more sensitive to radiation therapy and improves survival in animal models of the disease. The study, published Jan 21st in the International Journal of Radiation Oncology* Biology* Physics makes a strong case for moving this technology into clinical trials with breast cancer patients. “Finding a way
0 Comments
Tumor lysis syndrome (TLS) is a group of clinical and metabolic findings seen in patients with highly proliferative tumors who undergo chemotherapy. Cytotoxic chemotherapy can cause massive lysis of tumor cells, which leads to the release of multiple intracellular components into the bloodstream, including phosphate, potassium, and uric acid.1 This release can cause direct kidney
0 Comments
A recent study examines the relationship between colorectal cancer risk and high blood glucose levels, insulin levels, and insulin resistance in a cohort study. Colorectal cancer, which comprises cancers that originate in the colon or rectum, is one of the most commonly diagnosed cancers around the world. There is a noticeable correlation between colorectal cancer
0 Comments