Diabetes

50% of patients do not take their medicines as prescribed. What can we do about it? Jennifer K. Bussell, MD, FACP, is an expert who speaks nationally to the Institute for Healthcare Improvement on improving medication adherence and is involved in developing the medication adherence module for the AMA’s STEPS Forward Program. Q:
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A recent study evaluated the effectiveness of introducing weight management programs to help treat and potentially make a clinical difference in patients with diabetes. Given that type 2 diabetes is associated with obesity, a recent study published in Diabetes Obesity and Metabolism investigated whether the introduction of a weight management program has the potential to
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Every cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists at Joslin Diabetes Center have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may
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Clinical assessment There was no significant difference in age between control subjects and patients with diabetes (50.32 ± 2.92 vs. 55.97 ± 1.32, P = 0.08), but patients with DN+ were older (50.32 ± 2.92 vs. 62.08 ± 1.4, P = 0.001). Therefore, the values were adjusted for age using analysis of covariance (ANCOVA). BMI (kg/m2) (26.47 ± 1.15 vs. 29.58 ± 0.73, P = 0.029) and HbA1c (mmol/mol) (36.4 ± 1.02 (5.48%) vs. 57.49 ± 1.66
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1. Hex, N., Bartlett, C., Wright, D., Taylor, M. & Varley, D. Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet. Med. 29, 855–862 (2012). This article highlights the morbidity, mortality and economic costs of DKD. 2.
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Animals Six to eight-week-old female wild-type (WT) C57BL/6-(CD45.2), C57BL/6-(CD45.1), JNK1 knockout (JNK1−/−) C57BL/6 background, non-obese diabetic (NOD)/ShiLtJ, C3H/HeJ and 11 to 12-week-old female BALB/c mice were purchased from The Jackson Laboratories (Bar Harbor, ME, USA). The Institutional Animal Care and Use Committee of the University of Texas Health Science Center at Tyler approved the studies.
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Animals All mice were purchased from Charles River (Yokohama, Japan), and bred under pathogen-free conditions at the Kyushu University Animal Center (Fukuoka, Japan). All protocols were approved by the Ethics Committee of Kyushu University Graduate School of Medicine. All methods were performed in accordance with the approved institutional guidelines. Every effort was made to minimize
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Look back over the past 20 years of diabetes translation. The National Diabetes Education Program (NDEP) is a 20-year-old, federally funded program sponsored by the National Institutes of Health (NIH) and the Centers for Disease Control (CDC) and Prevention. The NDEP’s strength is in its partnership network, which
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1. Congdon, N. G., Friedman, D. S. & Lietman, T. Important causes of visual impairment in the world today. Journal of the American Medical Association 290(15), 2057–2060 (2003). 2. Tang, J. & Kern, T. S. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 30(5), 343–58 (2011). 3. Barber, A. J. et al. Neural apoptosis in
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Mice All animal experiments were approved by the Animal Care and Use Committee of Keio University. Eight- to 16-week-old male mice (db/db-C57BLKS, WT-C57BLKS, ob/ob-C57BL/6 J, Akita-C57BL/6 J, and WT-C57BL/6 J) were obtained from Charles River (Yokohama, Japan), group-housed, and provided with water and a standard laboratory diet ad libitum. All animals were bred and maintained in the animal
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The present study identifies a deleterious potentiation of impaired glucose homeostasis, β-cell dysfunction and chronic tissue inflammation by the combination of obesity and ageing. Data from our HFD/ageing mouse model support the concept that obesity with ageing leads to further deterioration in blood glucose regulation, which is likely due to a reduced capacity to balance
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System for single-cell analysis of human islets To study the heterogeneity of human islets at the single-cell level, we performed single-cell gene expression analyses of six different batches of human islets via the Fluidigm microfluidic platform (Fig. 1a and Supplementary Fig. 1A). Human islets and the reciprocal non-islet fractions were isolated in Canada and shipped to Singapore
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This is the first study to evaluate the association between serum IgE levels and DM in a general population. We found strong positive associations between total IgE, house dust mite and cockroach-specific IgE levels and DM, and these persisted after adjustment for many potential confounders, including lifestyle factors (alcohol consumption, smoking status, and regular exercise);
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Study design The first part of this study is a single-blind, randomized, two-way, cross-over study to examine the impact of overestimation of a meal insulin bolus in the context of dual-hormone closed-loop operation (insulin and glucagon) combined with a simplified semi-quantitative meal-size estimation in adults with type 1 diabetes. Two separate meals (75 g and 45 g
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Is knowing what’s best for diabetes the same as knowing what’s best for your patient? Martha Funnell, MS, RN, CDE, FAAN, an expert in diabetes care and self-management, patient education and psychosocial support, discusses the challenges of behavior change and patient-professional communication strategies. Q: Why is it important for health care professionals to consider
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Animals and cells Animal experiments procedures were approved by the Animal Care and Use Committee of the Capital Medical University (approval no. AEEI-2014-086). Male Sprague-Dawley (SD) rats weighing 180–220 g were obtained from the Experimental Animal Center at Capital Medical University, Beijing, China (SCXK 2012–0001) and were housed with a 12/12-hour light/dark cycle in a temperature
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1. Huynh, K., Bernardo, B. C., McMullen, J. R. & Ritchie, R. H. Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther. 142, 375–415 (2014). 2. Lam, C. S. Diabetic cardiomyopathy: An expression of stage B heart failure with preserved ejection fraction. Diab Vasc Dis Res. 12, 234–238 (2015). 3. Bugger,
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Antisera The following antisera were used in these studies: anti-IDE antibodies 9B12 (Abcam) and 402038, anti-LDH antibody Ab 52488 (Abcam), monoclonal anti-GAPDH (6C5) (Santa Cruz), rabbit antibody against the human pitrilysin sequence 753AEMTDIKPILRKLPRIKK (Bethyl Lab)38, monoclonal anti-Bip/GRP 78 (BD Transduction Laboratories), monoclonal anti-β-actin (C4) (Santa Cruz), monoclonal anti-Alix (1A12) (Santa Cruz), and monoclonal anti-flotillin-1 (BD
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1. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277–359 (2004). 2. Bartelt, A. et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17, 200–205 (2011). 3. Stanford, K.I. et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 123, 215–223 (2013).
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Animal experiments All animal experiments were approved by the Institutional Animal Care and Use Committee of Yonsei University, Wonju College of Medicine. C57BL/6 male mice were housed in a controlled environment with a 12 h dark/light cycle at a room temperature of 22–24 °C. Mice were divided into three experimental groups. The first group (n=4) was maintained
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In the above-mentioned article, the following errors were detected: In Fig. 2C displaying AKT and phosphorylated AKT (pAKT) expression in epididymal white adipose tissue (eWAT) and liver, the AKT immunoblotting was not the corresponding blot to the pAKT. The authors are replacing this figure with the corresponding total AKT in the liver and providing a
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On the basis of the recommendation of the American Diabetes Association’s Panel on Ethical Scientific Programs (ESP), the American Diabetes Association, the publisher of Diabetes, is issuing this expression of concern to alert readers to questions about the reliability of the data in the above-cited article. After readers of the journal contacted Diabetes about potentially
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1. Consoli, A., Nurjhan, N., Capani, F. & Gerich, J. Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM. Diabetes 38, 550–557 (1989). 2. Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G. & Shulman, G. I. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance
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1. Whitmore, A. An Account of a Glanders-like Disease occurring in Rangoon. J. Hyg. 13, 1–34.1 (1913). 2. Kaestli, M. et al. Out of the ground: aerial and exotic habitats of the melioidosis bacterium Burkholderia pseudomallei in grasses in Australia. Environ. Microbiol. 14, 2058–2070 (2012). 3. Limmathurotsakul, D. et al. Predicted global distribution of Burkholderia
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On the basis of the recommendation of the American Diabetes Association’s Panel on Ethical Scientific Programs (ESP), the American Diabetes Association, the publisher of Diabetes, is issuing this expression of concern to alert readers to questions about the reliability of the data in the above-cited article. After readers of the journal contacted Diabetes about potentially
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