Diabetes

On the basis of the recommendation of the American Diabetes Association’s Panel on Ethical Scientific Programs (ESP), the American Diabetes Association, the publisher of Diabetes, is issuing this expression of concern to alert readers to questions about the reliability of the data in the above-cited article. After readers of the journal contacted Diabetes about potentially
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By Max Bingham, PhD Success With In Vivo Imaging of β-Cell Mass The search for a noninvasive method to characterize β-cell mass continues with Eriksson et al. (p. 182) reporting an investigation into a radio-labeled small molecule GPR44 antagonist called [11C]AZ12204657 to visualize β-cells in vivo via positron electron tomography (PET). The authors say that
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PROFESSIONAL EDUCATION The American Diabetes Association offers a variety of continuing education opportunities and materials for health care professionals. Educational offerings include live and free online programs. For more information, including a complete list of American Diabetes Association programs, please visit professional.diabetes.org/ce. SCIENTIFIC SESSIONS The 78th annual American Diabetes Association Scientific Sessions will be held
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Abstract The Outstanding Scientific Achievement Award recognizes distinguished scientific achievement in the field of diabetes, taking into consideration independence of thought and originality. Gregory R. Steinberg, PhD, professor of medicine, Canada Research Chair, J. Bruce Duncan Endowed Chair in Metabolic Diseases, and codirector of the Metabolism and Childhood Obesity Research Program at McMaster University, Hamilton,
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During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic inflammation, redox changes, and intracellular stress responses to dysregulated energy metabolism, particularly insulin resistance (1). Autophagy, a lysosomal degradation pathway for damaged organelles
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1. Kopp, P. The TSH receptor and its role in thyroid disease. Cellular and molecular life sciences: CMLS 58, 1301–1322 (2001). 2. de Lloyd, A., Bursell, J., Gregory, J. W., Rees, D. A. & Ludgate, M. TSH receptor activation and body composition. The Journal of endocrinology 204, 13–20, https://doi.org/10.1677/JOE-09-0262 (2010). 3. Davies, T., Marians, R.
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1. Snyder, H. M. et al. Vascular contributions to cognitive impairment and dementia including Alzheimer’s disease. Alzheimers Dement. 11, 710–717 (2015). 2. Montine, T. J. et al. Recommendations of the Alzheimer’s disease-related dementias conference. Neurology 83, 851–860 (2014). 3. Stoeckel, L. E. et al. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic
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CRM imaging of alginate microbeads: validation, technical aspects, and quantitative analysis Alginate microbeads represent one of the most popular microsphere designs applied in the cell encapsulation field1, which can be ascribed to their well-documented immunoprotective character in various animal models and also to the overall simplicity of this one-component system. The preparation method allows for
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1. Cohen-Solal, A., Beauvais, F. & Logeart, D. Heart failure and diabetes mellitus: epidemiology and management of an alarming association. J. Card. Fail. 14, 615–625 (2008). 2. McMurray, J. J. et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N. Engl. J. Med. 371, 993–1004 (2014). 3. Kannel, W. B., Hjortland, M. & Castelli, W.
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Materials OA, neomycin (SIGMA, St. Louis, MO, USA), H-89 (Millipore, Billerica, MA, USA), GLP-1 (#22462, Anaspec, San Jose, CA, USA) and Xestospongin C (Enzo Life Sciences, Inc., Farmingdale, NY, USA) were commercially obtained. Rabbit antibodies to OLFR15 (NB110-75053, Novus Biologicals Inc., Littleton, CO, USA), OLFR821 (OSR00210W, Osenses, Australia), PLC-γ1 (#2822, Cell Signaling Technology, Beverly, MA,
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UT Southwestern researchers report that development of the endocrine pancreas is promoted by a weblike network of epithelial tubes that exist only transiently in the developing embryo. The findings, published online by Genes & Development, suggest that a deeper understanding of this endocrine differentiation “niche” could propel development of novel treatments for diabetes. Researchers from
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Quality filtering for imputed variants In order to assess genotype imputation quality and to determine an accurate post-imputation quality filter, we made use of the Wellcome Trust Case Control Consortium (WTCCC)40 data available through the European Genotype Archive (EGA, https://www.ebi.ac.uk/ega/studies/EGAS00000000028). The genotyping data and the subjects included in the following tests were filtered according to
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T2DM is a metabolic disease caused by both genetic and environmental factors. Vitamin D deficiency has been reported to be a risk factor for T2DM8. Thus, genetic variation in vitamin D metabolism-related genes may play a role in the development of T2DM20. CYP24A1 encoding the enzyme to degrade the active vitamin D metabolite 1,25(OH)2D plays
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1. Finkelstein, E. A. et al. Obesity and severe obesity forecasts through 2030. Am. J. Preventive Med. 42, 563–570 (2012). 2. Malik, V. S., Willett, W. C. & Hu, F. B. Global obesity: trends, risk factors and policy implications. Nat. Rev. Endocrinol. 9, 13–27 (2013). 3. Kahn, S. E., Hull, R. L. & Utzschneider, K.
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1. Finkelstein, E. A. et al. Obesity and severe obesity forecasts through 2030. Am. J. Preventive Med. 42, 563–570 (2012). 2. Malik, V. S., Willett, W. C. & Hu, F. B. Global obesity: trends, risk factors and policy implications. Nat. Rev. Endocrinol. 9, 13–27 (2013). 3. Kahn, S. E., Hull, R. L. & Utzschneider, K.
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Materials Chemicals were purchased from Sigma-Aldrich (Germany), Roche (Germany) and New England Biolabs (Germany). Animal studies Human islet amyloid polypeptide protein (hIAPP) transgenic mice, which overexpress the hIAPP protein under the control of rat insulin II promoter, were purchased from Jackson Laboratories (USA)24. To distinguish between tg/tg and wt/tg mice genomic DNA was isolated and
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Materials and reagents Unless otherwise stated all research materials were obtained from Thermo Fisher Scientific and Sigma-Aldrich. Mouse islet and β-cell isolation and culture Animals were handled in compliance with the Guide for the care and use of laboratory animals, Eighth edition (2011) (http://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf) and in line with guidelines approved by the Vanderbilt University Animal
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In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published Jan. 16 in JAMA Internal Medicine. “We found a very strong association between breastfeeding duration and lower risk of developing
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Study design and participants The baseline data of a prospective study was used to validate the tool. Eleven tertiary hospitals from nine provinces or municipalities of China (North: Beijing, Hubei; West: Sichuan, Qinghai; East: Shanghai, Jiangxi; South: Macau, Hunan, Hubei) were selected through non-probability sampling. Diabetic patients were recruited from November to December 2015 and
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In the present study, the complex I activity, mitochondrial membrane potential, mitochondrial respiration, and mitochondrial ATP production were analyzed among two mutation-undetectable and two mutation-high Mt iPS cell clones from two patients with the A3243G mutation of different pedigrees. In addition, the complex I activity and mitochondrial respiration of the mutation-undetectable Mt iPS cell clones
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1. Huxley, R., Barzi, F. & Woodward, M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 332(7533), 73–8 (2006). 2. Kannel, W. B., Hjortland, M. & Castelli, W. P. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol.
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Protocol and registration This systematic review and meta-analysis follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol8 and was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42016953346. Patient Involvement No patients were directly involved in the study. Information source and search strategy We
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1. Pringsheim, T. & Gardner, D. M. Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study. CMAJ Open 2, E225–232, https://doi.org/10.9778/cmajo.20140009 (2014). 2. Maher, A. R. et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA
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Researchers reviewed data from twenty prospective studies to analyze the relationship between omega-6 fatty acids and type 2 diabetes. Omega-6 polyunsaturated fatty acids (PUFAs) are found in nuts, seeds, and edible oils (such as most vegetable oils). They play an important role in growth and development. Certain clinical guidelines, such as the American Heart Association
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