Drugs

Researchers in Scotland investigate the prevalence and safety of using both herbal remedies and prescription medications during pregnancy. Many women are prescribed medications during pregnancy, often to treat pregnancy-related conditions such as nausea or to improve fetal development. The effects of these medications are fairly well studied, as are their potential risks. However, many women
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Researchers in Switzerland investigate the prevalence and determinants of vitamin D deficiency in pregnant women during their third trimester. Vitamin D is critical for normal human growth and development. However, vitamin D deficiency is a widespread health problem today and affects populations all over the world. Recently, vitamin D deficiency in pregnant women and the
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In a recent study, researchers investigated the reliability of doctors’ examination findings in assessing children with suspected pneumonia.   How Do We Diagnose Pneumonia? Children with respiratory illnesses are often assessed in hospital emergency departments to check for pneumonia which may need treatment with antibiotics. The Pediatric Infectious Diseases Society Consensus Guidelines strongly recommend that
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In a recent study, researchers developed a series of cell lines that may form the basis of a drug screen platform for breast cancer using organoids.   Applying breast cancer therapies that are appropriate for a specific tumour’s composition, behaviour, and the specific mechanisms which allow it to grow, spread, and survive remains a challenge.
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Levels of a protein found in the brain called alpha-synuclein (α-syn) are significantly lower than normal in cerebrospinal fluid collected in Parkinson’s disease patients suffering from postural instability and gait difficulty, a study led by movement disorders experts at Rush University Medical Center has found. The results recently were published online in the journal Movement
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Tohoku University researchers have improved on currently available methods for screening drugs for heart-related side effects. The method involves fabricating a tiny hole in a silicon chip over which lipid membranes, similar to those that surround cells, are encouraged to grow. An ion channel is then synthesized separately and knocked into the membrane during centrifugation.
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A team of researchers at the Center for Self-assembly and Complexity, within the Institute for Basic Science (IBS) have observed a normal physiological process, called “self-eating,” that cells use to recycle their components. They developed an accurate technique that visualizes how mitochondria, cells’ energy factories, are fused with lysosomes, cells’ recycling machines, in order to
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Experts in Italy evaluated the available research to outline ten “golden rules” when using probiotics to improve health and treat medical conditions. Probiotics are live microorganisms that can improve health. There has been an explosion of interest in probiotics in the recent years, with several claims made about their benefits for digestive health, allergic disorders,
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Researchers have found that excess levels of calcium in brain cells may lead to the formation of toxic clusters that are the hallmark of Parkinson’s disease. The international team, led by the University of Cambridge, found that calcium can mediate the interaction between small membranous structures inside nerve endings, which are important for neuronal signalling
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Parkinson’s disease is a progressive neurodegenerative disease that typically affects adults over 65 years old. Researchers recently investigated if caffeine and caffeine metabolites can be used as biomarkers to effectively diagnose Parkinson’s disease. Parkinson’s disease is a neurodegenerative disorder that progressively leads to loss of bodily movement. Currently, it is estimated that 55,000 Canadians (0.2% of the Canadian population) are living with Parkinson’s disease, making
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Obese pregnant women have higher risks of complications during pregnancy and childbirth. Researchers recently identified maternal characteristics that are associated with uncomplicated pregnancies and births. Obese pregnant women have higher risks of complications during pregnancy and at birth compared to non-obese pregnant women including gestational diabetes mellitus (GDM), preeclampsia, and emergency caesarian sections. All obese
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Researchers evaluate the promising results of a new drug candidate, SAAP-148, giving new hope in overcoming drug-resistant bacteria. The rise of drug-resistant bacteria has long been a topic of concern as it poses a great risk to human health. Hospital-acquired infections are often caused by drug-resistant bacteria strains that possess the ability to form biofilms,
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Experimental activation of a small set of nerve cells in the brain prevents convulsive seizures in a mouse model of temporal lobe epilepsy, the most common form of epilepsy among human adults, according to a study by researchers at the Stanford University School of Medicine. In contrast, inactivating these cells, known to neuroscientists as mossy
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A recent research study investigates whether fluorouracil cream can be used to prevent skin cancer such as keratinocyte carcinomas or melanomas. Keratinocyte carcinoma (KC) are types of skin cancers where malignant cells develop in either the basal or squamous skin cell layers. Different from melanomas, keratinocyte carcinomas do not have the same frightening symptoms, such
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A study published in BMC Pregnancy and Childbirth aimed to provide evidence that behaviour change interventions can reduce secondhand-smoke exposure in pregnant women. The number of daily smokers has increased with a high prevalence of smoking in men. Exposure to second-hand smoke can result in various health outcomes, such as ischemic heart disease, lower respiratory
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Scientists at Imperial College London have become the first in the world to test how pathogens interact with artificial human organs. Artificial human organs, or organ-on-chip technologies, simulate a whole organ’s cell make up and physiology. They act as alternatives to animal models in drug safety testing, but until now they have not been used
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A recent article discusses whether doctors should start using apoB tests instead of the standard cholesterol tests to measure cardiovascular disease risk. Based on the current guidelines, normal cholesterol panel tests include HDL cholesterol (high density lipoprotein) and LDL cholesterol (low density lipoprotein). Recent findings suggest that other cholesterol markers might be a better indicator
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